Usefulness of Ondansetron versus Dexamethasone as Postoperative Antiemetic Prophylaxis during Major Gynecologic Surgery

Authors

  • Armando González López Hospital Clíico Quirúrgico Docente Miguel Enríquez
  • Laura Garí Marcos Hospital Clíico Quirúrgico Docente Miguel Enríquez
  • José A. López Roca Hospital Clíico Quirúrgico Docente Miguel Enríquez
  • Arani María Sarabia Albor Hospital Clíico Quirúrgico Docente Miguel Enríquez
  • Giselle Romero Gregorich Hospital Clíico Quirúrgico Docente Miguel Enríquez

Keywords:

postoperative nausea and vomiting, dexamethasone, ondansetron

Abstract

Introduction: Postoperative nausea and vomiting are an unwanted sequel during the anesthetic recovery stage.

Objective: To evaluate the usefulness of dexamethasone compared with ondansetron for the prevention of postoperative nausea and vomiting after major gynecological surgical procedures, under general orotracheal anesthesia.

Method: A prospective, analytical and observational study was carried out with 84 patients older than 19 years of age, at Miguel Enríquez Hospital Clinical-Surgical Hospital, from October 2018 to September 2019, divided sequentially, in order of arrival at the surgical unit, into two groups. The group 1 was administered dexamethasone (4 mg intravenously), and the group 2 was administered ondansetron (4 mg), 30 min before the end of the surgery.

Results: The average risk of postoperative nausea and vomiting prevailed significantly among patients aged 41-50 years. Excellent and good conditions predominated (p>0.05) in terms of effectiveness of prophylactic treatment. Headache prevailed significantly in the group 2. Most of the patients did not present adverse events.

Conclusions: Ondansetron and dexamethasone are useful for postoperative nausea and vomiting prophylaxis among patients who received major gynecological surgery, under general orotracheal anesthesia, a reason why it is considered a safe treatment, with mild adverse events and easy control.

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Author Biographies

Armando González López, Hospital Clíico Quirúrgico Docente Miguel Enríquez

Graduado de médico general en el año 1991 en la Universidad de Ciencias Médicas deLa Habana.

Título de especialista de Promer Grado en Anestesiología y Reanimación en el año 1997 otorgado por el tribunal estatal del Hospital Docente: Manuel Fajardo.

Estudios de posgrado de la especialidad durante 4 años fueronrealizados en el Instituto Superiorde Medicina Militar Dr. Luis Díaz Soto, donde, después de graduado se desempeño como especialista hasta el año 2004.

Actualmente se desempeña como especialista y docente en el servicio de Anestesiología y Reanimación del Hospital docente. Miguel Enriquez en La Habana, Cuba.

Laura Garí Marcos, Hospital Clíico Quirúrgico Docente Miguel Enríquez

Especialista de Segundo Grado en Anestesiología y Reanimación

José A. López Roca, Hospital Clíico Quirúrgico Docente Miguel Enríquez

Especialista de Primer Grado en Anestesiología y Reanimación

Arani María Sarabia Albor, Hospital Clíico Quirúrgico Docente Miguel Enríquez

Residente en Anestesiología y Reanimación

Giselle Romero Gregorich, Hospital Clíico Quirúrgico Docente Miguel Enríquez

Residente en Anestesiología y Reanimación

Published

2020-03-24

How to Cite

1.
López AG, Garí Marcos L, López Roca JA, Sarabia Albor AM, Romero Gregorich G. Usefulness of Ondansetron versus Dexamethasone as Postoperative Antiemetic Prophylaxis during Major Gynecologic Surgery. Rev Cub Anest Rean [Internet]. 2020 Mar. 24 [cited 2025 Jan. 8];19(3). Available from: https://revanestesia.sld.cu/index.php/anestRean/article/view/629

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