Variations in Blood Chemistry as an Indicator of Redox Status during Anesthesia and Surgery

Authors

Keywords:

estrés oxidativo; anestesia; radicales libres; especies reactivas del oxígeno; perioperatorio.

Abstract

Introduction: During anesthesia and surgery, patients experience an imbalance in their redox status as a result of the profound physiological changes that occur during this period. The loss of balance between prooxidant and antioxidant compounds leads to cellular damage, which can be detected by screening for various biomarkers of redox status.

Objective: To describe the behavior of indirect biomarkers of redox imbalance during anesthesia and surgery.

Methods: A descriptive, prospective study was conducted at the Dr. Luis Díaz Soto Central Military Hospital between August 2023 and May 2024. The universe consisted of all patients who underwent surgery for acute appendicitis during that time, so the sample consisted of 80 patients who met the criteria established for the study.

Results: The study yielded significant results, with increases in blood glucose, uric acid, urea, creatinine, and malondialdehyde, and decreases in total protein, albumin, amylase, bilirubin, alkaline phosphatase, aspartate aminotransferase, and reduced glutathione.

Conclusions: Redox imbalance during the transoperative period can be detected by quantifying blood chemistry compounds.

 

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Published

2025-09-11

How to Cite

1.
Gúzman Martínez JK, Vasallo Comendeiro VJ, Viscaíno Cesar M, Abreu Brioso GL, Rodríguez Bonet T, Figueroa Vetía Y. Variations in Blood Chemistry as an Indicator of Redox Status during Anesthesia and Surgery. Rev Cub Anest Rean [Internet]. 2025 Sep. 11 [cited 2025 Sep. 12];24. Available from: https://revanestesia.sld.cu/index.php/anestRean/article/view/2265

Issue

Vol. 24 (2025): In progress

Section

Original articles

License

Copyright (c) 2025 Juan Karel Gúzman Martínez, Víctor José Vasallo Comendeiro, Maritania Viscaíno Cesar, Gisell Lidia Abreu Brioso, Tamara Rodríguez Bonet, Yanira Figueroa Vetía

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